Lou’s Sweet-Heat Meatloaf with Buttermilk Panade and Tangy Glaze

Moist, tender, and packed with flavor — this sweet-heat meatloaf uses a buttermilk panade for incredible texture and a tangy glaze for the perfect finish.

Aug 13, 2025

Lou’s Sweet-Heat Meatloaf with Buttermilk Panade and Tangy Glaze

There’s nothing like a great meatloaf, and Lou’s Sweet-Heat Meatloaf delivers big on flavor and texture. A buttermilk-soaked fresh bread panade keeps every slice moist and tender, while a sweet-smoky blend of BBQ sauce, molasses, and sriracha brings depth to the mix. Finished with a tangy ketchup-honey glaze, this meatloaf hits the perfect balance — savory, sweet, and just enough heat to keep things interesting. Whether it’s your Sunday dinner centerpiece or next-day sandwich hero, this recipe is built for comfort and flavor in every bite.

Ingredients

Meatloaf:
  • 2½ lbs meatloaf mix (beef, pork, veal)
  • 3–3½ cups fresh bread cubes (soft interior, crusts optional, torn or cut small)
  • 2 cups buttermilk (for panade)
  • 1 large onion, finely diced
  • 1 large carrot, grated
  • 1 celery stalk, finely diced
  • 3 cloves garlic, minced
  • 1 tsp dried thyme (from the wife’s garden)
  • 2 large eggs, lightly beaten
  • 2½ tbsp French’s yellow mustard
  • 2½ tbsp Stubb’s BBQ sauce
  • 1¼ tbsp Grandma’s molasses
  • 1¼ tsp sriracha
  • 1¼ tbsp Worcestershire sauce
  • 1½ tsp Kinder’s All Purpose seasoning
  • Kosher salt & black pepper, to taste
Glaze:
  • ⅔ cup ketchup
  • 2½ tbsp honey
  • 2 tsp Crystal hot sauce
  • 1¼ tbsp apple cider vinegar

Instructions

  1. Make the mirepoix
    1. Heat olive oil in a skillet over medium heat. Add onion, grated carrot, celery, garlic, and thyme. Season with a pinch of salt and cook until softened and fragrant, about 5 minutes. Let cool slightly — this will be mixed with the eggs and seasonings.
  1. Build the panade
    1. Place torn or cut bread cubes in a large mixing bowl. Pour in 2 cups buttermilk and mash gently with a fork until fully moistened. Let rest 5 minutes so the bread fully absorbs the buttermilk, breaking down slightly but keeping some texture.
  1. Build the base mix
    1. In a second large bowl, whisk eggs with mustard, BBQ sauce, molasses, sriracha, Worcestershire, Kinder’s seasoning, salt, pepper, and the cooled mirepoix. Mix well until uniform.
      Ready for seasoning sir!
      Ready for seasoning sir!
  1. Add panade and meat
Add half the panade to the egg/mirepoix mixture. Add the meatloaf mix and combine gently with your hands. Goldilocks note: You may not need more panade. The mixture should be soft but able to form into a loaf — it should feel like bread dough that can hold its shape without being stiff. Gradually add more panade only if needed. Cook a small patty in a skillet, taste, and adjust seasoning before shaping.
Leftover Panade
Leftover Panade
  1. Shape and bake
    1. Shape into a loaf on a parchment-lined sheet pan or in a foil-lined loaf pan. Bake at 350°F for about 50 minutes.
      All Ready For The Oven
      All Ready For The Oven
       
  1. Glaze and finish
    1. Whisk glaze ingredients until smooth. Brush generously over the loaf and bake an additional 15–20 minutes, until internal temp reaches 160°F.
  1. Rest and slice
    1. Let rest 10 minutes before slicing so juices redistribute.
      Ready to Enjoy! I know I had seconds.
      Ready to Enjoy! I know I had seconds.